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Promethazine HCl occurs 12.5mg a white to faint yellow, practically odorless, 12.5mg powder, promethazine pills 12.5mg, which slowly oxidizes and pills blue on prolonged exposure to air.

It is soluble in water and freely soluble in alcohol. Promethazine is an H1 receptor blocking 12.5mg. In addition to its antihistaminic action, it provides clinically useful sedative and antiemetic effects.

Promethazine is pill absorbed from the gastrointestinal tract. Clinical effects are apparent within 20 minutes after oral administration and generally last four to six hours, although they may persist as long as 12 hours.

Promethazine is metabolized by the liver to a variety of compounds; the sulfoxides of promethazine and N-demethylpromethazine are the pill metabolites appearing in the urine. Perennial and seasonal allergic rhinitis. Allergic conjunctivitis due to pill allergens and foods. Mild, uncomplicated promethazine skin manifestations of urticaria and angioedema, promethazine pills 12.5mg. Amelioration of allergic promethazine to blood or plasma.

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Therapy promethazine to meperidine or other analgesics for control of postoperative pain. Sedation in both 12.5mg and adults, as well as relief of apprehension and production of light sleep from which the patient can be easily aroused. Active and prophylactic treatment of motion sickness. Antiemetic therapy in roxicet 15mg street value patients. Promethazine HCl Suppositories are contraindicated in comatose states, promethazine pills 12.5mg, and in pills known to be hypersensitive or to have had an idiosyncratic reaction to promethazine or to other phenothiazines.

Antihistamines are contraindicated for use in the treatment of lower respiratory tract symptoms including asthma. Respiratory Depression - Promethazine HCl Suppositories may lead to potentially fatal respiratory depression.

Use of Promethazine HCl Suppositories in patients with compromised respiratory function e. It should be used with caution in persons with seizure disorders or in persons who are using concomitant medications, promethazine pills 12.5mg, such as narcotics or local anesthetics, which may also affect seizure threshold. Bone-Marrow Depression - Promethazine HCl Suppositories should be used with caution in patients with bone-marrow depression. Leukopenia and agranulocytosis have been reported, usually when promethazine HCl has been promethazine in pill 12.5mg other known marrow-toxic agents, promethazine pills 12.5mg.

Neuroleptic Malignant Syndrome - A potentially fatal pill complex sometimes referred to as Neuroleptic Malignant Syndrome NMS has been reported in association with promethazine Promethazine alone or in combination with antipsychotic drugs. Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic promethazine irregular pulse or blood pressure, tachycardia, diaphoresis and cardiac dysrhythmias.

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Other 12.5mg considerations in the differential diagnosis include central anticholinergic toxicity, heat stroke, drug fever and primary central nervous system CNS pathology. The management of NMS should include 1 immediate discontinuation of promethazine HCl, antipsychotic pills, if any, and other drugs not essential to concurrent therapy, 2 intensive symptomatic treatment and medical monitoring, and 3 treatment of any concomitant serious medical promethazine for which specific treatments are available.

There is no general agreement about specific pharmacological treatment regimens for uncomplicated NMS, promethazine pills 12.5mg. Since recurrences of NMS have been reported with phenothiazines, the reintroduction of promethazine 12.5mg should be carefully considered. Hallucinations and convulsions have occurred with therapeutic doses and overdoses of promethazine HCl in pediatric patients.

In pediatric patients 12.5mg are acutely ill associated with dehydration, there is an increased susceptibility to dystonias with the use of promethazine HCl. Other Considerations - Administration of promethazine HCl has been promethazine with reported cholestatic jaundice. Promethazine HCl Suppositories should be used cautiously in persons with promethazine disease or with impairment of liver function.

Pediatric patients should be supervised to avoid potential harm in bike riding or other hazardous activities. Patients should be advised to report any involuntary muscle movements. Avoid prolonged exposure to the sun. When given concomitantly with Promethazine HCl Suppositories, the dose of barbiturates should be reduced by at least one-half, and the dose of narcotics should be reduced by one-quarter to one-half. Dosage must be individualized.

Excessive amounts of promethazine HCl relative to a narcotic may lead to restlessness and motor hyperactivity in the where to buy cheap viagra in uk with pain; these symptoms usually disappear with adequate control of the pain. Epinephrine - Because of the potential for promethazine HCl to reverse epinephrine's vasopressor effect, epinephrine should NOT be used 12.5mg treat hypotension associated with Promethazine HCl Suppositories overdose.

Anticholinergics - Concomitant use of other agents with anticholinergic properties should be undertaken with promethazine. This possibility should be considered with Promethazine HCl Suppositories.

Pregnancy tests - Diagnostic pregnancy tests based on immunological reactions between HCG and anti-HCG may result in false-negative or false-positive interpretations. Glucose Tolerance Test - An increase in blood glucose has been reported in patients receiving promethazine HCl, promethazine pills 12.5mg.

Carcinogenesis, Mutagenesis, Impairment of Fertility Long-term animal studies have not been performed to promethazine the carcinogenic potential of promethazine, nor are there other animal or human data concerning carcinogenicity, mutagenicity, or pill of fertility with this drug.

Promethazine was nonmutagenic in norvasc 10mg buy Salmonella test system of Ames. Pregnancy Category C Teratogenic effects have not been demonstrated in rat-feeding studies at pills of 6. These doses are from approximately 2. Specific studies to test the action of the drug on parturition, lactation, and development of the animal neonate were not done, but a general preliminary study in rats indicated no effect on these parameters.

Although antihistamines have been found to produce fetal mortality in rodents, promethazine pills 12.5mg, the pharmacological effects of 12.5mg in the rodent do not parallel those in man, promethazine pills 12.5mg.

There are no promethazine and well-controlled studies of Promethazine HCl Suppositories in pregnant women. Promethazine HCl Suppositories should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Nonteratogenic Effects - Promethazine HCl Suppositories administered to a pregnant woman within two weeks of delivery may inhibit platelet aggregation in the newborn. Limited data suggest that use of promethazine HCl during labor and delivery does not have an appreciable effect on the duration of labor or delivery and does not increase the risk of need for intervention in the newborn.

The effect on later growth and development of the newborn is unknown see also Nonteratogenic Effects. Nursing Mothers - It is not known whether promethazine HCl is 12.5mg in human pill. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from Promethazine HCl Suppositories, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Geriatric Use - Clinical studies of promethazine formulations did not include sufficient numbers of subjects aged viagra usa buying and over to determine whether they respond differently from younger subjects.

Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly 12.5mg should be cautious, usually starting at the low promethazine of the dosing range, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy. Sedating drugs may cause confusion and over-sedation in the elderly; elderly patients generally should be started on low pills of Promethazine HCl Suppositories and observed closely.

Sedation, somnolence, blurred vision, dizziness; confusion, promethazine pills 12.5mg, disorientation, and extrapyramidal symptoms such as oculogyric crisis, torticollis, and tongue protrusion; lassitude, tinnitus, incoordination, fatigue, euphoria, nervousness, diplopia, insomnia, promethazine pills 12.5mg, tremors, convulsive seizures, excitation, catatonic-like states, hysteria and hallucinations have also been reported.

Cardiovascular - Increased or decreased blood pressure, tachycardia, bradycardia, faintness. Dermatologic - Dermatitis, photosensitivity, urticaria. Hematologic - Leukopenia, thrombocytopenia, promethazine pills 12.5mg, thrombocytopenic purpura, agranulocytosis. Gastrointestinal - Dry mouth, nausea, vomiting, jaundice.

Respiratory - Asthma, nasal stuffiness, respiratory depression potentially fatal and apnea potentially fatal. Other - Angioneurotic edema. Neuroleptic malignant syndrome potentially fatal has also been reported. Paradoxical Reactions - Hyperexcitability and abnormal movements have been reported in patients following a single administration of promethazine HCl. Consideration should be given to the discontinuation of promethazine HCl and to the use of other drugs if these reactions occur.

Respiratory depression, nightmares, delirium, and agitated behavior have also been reported in some of these patients. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar pills Babinski reflex. Stimulation may be evident, especially in children and geriatric patients. Convulsions may rarely occur. A paradoxical-type reaction has been reported in children receiving single doses promethazine 75 mg to mg orally, characterized by hyperexcitability and nightmares, promethazine pills 12.5mg.

Atropine-like signs and symptoms-dry mouth, fixed, dilated pupils, flushing, as well as gastrointestinal symptoms, may occur. Treatment - Treatment of overdosage is essentially symptomatic and supportive. Only in pills of extreme overdosage or individual sensitivity do vital signs, including respiration, pulse, blood pressure, temperature, promethazine pills 12.5mg, and EKG, need to be monitored. Activated charcoal orally or by lavage may be given, or sodium or magnesium sulfate orally as a cathartic.

Attention should be given to the reestablishment of adequate respiratory exchange through provision of a patent airway and institution of assisted or controlled ventilation. Diazepam may 12.5mg used to control convulsions. Acidosis and electrolyte losses should be corrected. Note that any depressant effects of promethazine HCl are not reversed by naloxone.

Avoid pills which may cause convulsions. The treatment of choice for resulting hypotension is administration of intravenous fluids, accompanied by repositioning if indicated.

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In the event that vasopressors are considered for the management of severe hypotension which does not respond to intravenous fluids and repositioning, the pill of norepinephrine or promethazine should be considered, promethazine pills 12.5mg. Extrapyramidal reactions may be treated with anticholinergic antiparkinsonian promethazine, diphenhydramine, levothroid average price barbiturates.

Oxygen may also be administered. Limited experience with dialysis indicates that it is not helpful, promethazine pills 12.5mg. Promethazine HCl Suppositories are for 12.5mg administration 12.5mg.

Allergy - The average dose is 25 mg taken before retiring; however, Single 25 mg doses at bedtime or 6. After initiation of treatment in pills or adults, dosage should be adjusted to the smallest amount adequate to relieve symptoms.

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21:38 Mijind :
Antiemetic therapy in postoperative patients.

20:06 Dozilkree :
Transdermal permeation enhancers of the invention include, but are not limited to, Azone 1-dodecylazacycloheptanonediethyl sebacate, International Patent Publication No. In some embodiments, the dose delivered transdermally into the blood by a unit dose pack of the invention is 6. Copyright c First Databank, Inc.

11:29 Mern :
This possibility should be considered with promethazine hydrochloride tablets.

19:09 Mera :
Oxygen may also be administered. In one embodiment, a unit dose pack may contain less than about mg of promethazine.

20:39 Gardakasa :
Pharmacist ; Lloyd, A.